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Zenpep (Pancrelipase) Shopper Approved

Prescription Prescription Required FormationFormulation: Capsule DR

Zenpep

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Prescription Prescription Required FormationFormulation: Capsule DR

Pancrelipase

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Zenpep (active ingredient: pancrelipase) is a prescription medication indicated for the treatment of exocrine pancreatic insufficiency (EPI) due to cystic fibrosis or other conditions. Zenpep is categorized as a digestive enzyme supplement and belongs to the drug class known as pancreatic enzyme products (PEPs).

Zenpep is prescribed to aid in the digestion of food in individuals who have difficulty breaking down and absorbing nutrients due to insufficient pancreatic enzymes. Conditions that may lead to EPI and require Zenpep include:

  • Cystic Fibrosis: A genetic disorder affecting the lungs and digestive system, leading to thick, sticky mucus production that can obstruct the pancreas and other organs.
  • Chronic Pancreatitis: A long-standing inflammation of the pancreas that alters its normal structure and functions, often resulting in EPI.
  • Pancreatectomy: Surgical removal of the pancreas or part of it, which can cause a deficiency in digestive enzymes.
  • Pancreatic Cancer: Malignant growth in the pancreas that can interfere with its ability to produce enzymes.
  • Other Conditions: Any disease or surgery that results in decreased production or secretion of pancreatic enzymes, such as gastrointestinal surgery or conditions like Shwachman-Diamond syndrome.

General Dosage Guidelines

Zenpep dosage is individualized based on the severity of the patient’s pancreatic insufficiency, their dietary fat intake, and their weight. The goal is to improve digestion and nutrient absorption by providing an adequate amount of enzymes.

  1. Initial Dosage for Adults and Children:
    • The starting dose is typically based on the estimated fat content of meals.
    • For infants up to 12 months, the starting dose is 2,000 to 4,000 lipase units per 120 mL of formula or breastfeeding.
    • For children older than 12 months and adults, the starting dose is 500 lipase units per kilogram of body weight per meal, up to a maximum of 2,500 lipase units per kilogram of body weight per meal or snack.
  2. Dose Adjustments:
    • The dosage may be adjusted according to the clinical response, dietary fat intake, and the occurrence of symptoms such as steatorrhea (fatty stools).
    • The total daily dose should not exceed 10,000 lipase units per kilogram of body weight per day.

Administration Instructions

  1. With Meals and Snacks:
    • Zenpep should be taken with every meal or snack. It is essential that Zenpep is ingested during meals to ensure that enzymes are present when food is in the stomach and small intestine.
  2. Swallowing Capsules:
    • Zenpep capsules should be swallowed whole with sufficient liquid to ensure they reach the stomach.
    • For those who cannot swallow capsules, the capsules can be carefully opened and the contents sprinkled on a small amount of soft, acidic food (pH ≤ 4.5) such as applesauce. This mixture should be consumed immediately without chewing to avoid damaging the enteric-coated microspheres.

Zenpep, like all medications, may cause side effects, although not everyone will experience them. The most common side effects are generally gastrointestinal in nature. Patients may experience symptoms such as abdominal pain, flatulence, and diarrhea. These are typically mild and may subside as the body adjusts to the medication. However, if these symptoms persist or become severe, it is important to consult a healthcare provider.

In some cases, patients taking Zenpep may experience more serious side effects. These can include allergic reactions characterized by itching, rash, hives, or swelling of the face, lips, or throat. An allergic reaction can also cause difficulty breathing or swallowing, which requires immediate medical attention.

Zenpep has been associated with fibrosing colonopathy, a rare but serious condition characterized by the formation of fibrous tissue in the colon, which can lead to bowel obstruction. This risk appears to be higher with high doses of pancreatic enzyme products.

Other potential side effects of Zenpep can include hyperuricemia (elevated uric acid levels in the blood) and hyperuricosuria (elevated uric acid levels in the urine), which may lead to gout or kidney stones. Patients with a history of gout or kidney problems should be monitored closely while taking Zenpep. Joint pain and muscular pain are also reported but occur less frequently.

Before starting treatment with Zenpep, it is important to consider several precautions to ensure the medication is used safely and effectively. Patients should provide their healthcare provider with a complete medical history, including any known allergies, especially to pork products, as Zenpep is derived from porcine pancreas. Individuals with a history of hypersensitivity to pancreatic enzymes or any other component of the product should not use Zenpep.

Patients with a history of gastrointestinal conditions, such as Crohn’s disease, ulcerative colitis, or any form of intestinal blockage, should inform their healthcare provider before starting Zenpep. The medication can exacerbate these conditions or mask their symptoms, leading to complications. Regular monitoring and appropriate dose adjustments are necessary for patients with these conditions to prevent adverse effects.

Zenpep may also affect uric acid levels in the blood and urine, potentially leading to gout or kidney stones. Patients with a history of gout, hyperuricemia, or kidney problems should be monitored closely while taking Zenpep. It is crucial to maintain adequate hydration to help minimize the risk of kidney stone formation and other renal complications.

There is a rare but serious risk of fibrosing colonopathy, particularly with high doses of pancreatic enzyme products. This condition involves the development of fibrous tissue in the colon, which can lead to bowel obstruction. Patients should use the lowest effective dose of Zenpep and report any unusual gastrointestinal symptoms, such as severe abdominal pain, constipation, or changes in bowel habits, to their healthcare provider immediately.

Zenpep can interact with other medications, potentially altering their effectiveness or increasing the risk of adverse effects. Patients should inform their healthcare provider of all medications they are taking, including prescription drugs, over-the-counter medications, and dietary supplements. Certain medications, such as antacids, may affect the absorption and effectiveness of Zenpep, necessitating careful management and timing of doses.

Pregnant or breastfeeding women should discuss the potential risks and benefits of using Zenpep with their healthcare provider. Although there is limited data on the use of Zenpep in pregnant or breastfeeding women, the potential for harm to the fetus or infant cannot be ruled out. The decision to use Zenpep should be based on a careful assessment of the risks and benefits.

Regular follow-up appointments with a healthcare provider are essential to monitor the patient’s response to Zenpep and adjust the dosage as needed. Any new or worsening symptoms should be reported promptly to ensure appropriate management. By adhering to these precautions and following the prescribed dosage and administration guidelines, patients can safely benefit from Zenpep in managing exocrine pancreatic insufficiency.

What is an alternative to Zenpep?

Several alternative medications to Zenpep can be used to manage exocrine pancreatic insufficiency (EPI). These alternatives are also pancreatic enzyme products (PEPs) that contain a mixture of digestive enzymes, primarily lipase, amylase, and protease, to aid in the digestion of fats, carbohydrates, and proteins. Some common alternatives include:

  1. CreonCreon is another widely used pancreatic enzyme replacement therapy. Like Zenpep, it contains pancrelipase and is used to treat EPI caused by conditions such as cystic fibrosis, chronic pancreatitis, and pancreatectomy. Creon is available in various strengths to tailor the dosage to individual patient needs.
  2. PertzyePertzye is another alternative containing pancrelipase. It is indicated for EPI and is known for its unique bicarbonate-buffered enteric coating, which helps to optimize the release of enzymes in the small intestine. Pertzye is available in multiple strengths to meet different patient needs.

What foods should I avoid when taking Zenpep?

When taking Zenpep, avoid high-fiber foods like whole grains and certain vegetables, high-fat foods such as fried items and processed meats, and acidic foods and beverages like citrus fruits, tomato products, and carbonated drinks. These can interfere with Zenpep’s effectiveness or worsen your condition.

Avoid alcohol, as it can irritate the pancreas and exacerbate symptoms of exocrine pancreatic insufficiency (EPI).

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Additional Information Book
Generic name:

Pancrelipase

Formulation:

Capsule DR

Strength(s):

5000U, 15000U, 25000U, 40000U

Quantities Available:

100

Why customers love Online Pharmacies Canada

Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.

Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.

How to Order

Can I buy Zenpep from Canada?

Absolutely, you can buy Zenpep from Canada via Online Pharmacies Canada. Many individuals choose Canadian pharmacies because they offer potential savings on costs.

Is it safe to buy Zenpep from Canada?

Buying Zenpep from a reputable Canadian pharmacy like Online Pharmacies Canada is considered safe. Online Pharmacies Canada is verified by the Canadian International Pharmacy Association (CIPA). CIPA-approved pharmacies are recognized as safe in the US.

We encourage you to read our pharmacy reviews from verified customers before making a purchase decision.

How much Zenpep can I order?

When ordering Zenpep from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time.

Here’s what you need to know:

  • Zenpep is available in various strengths, typically ranging from 3,000 to 40,000 lipase units per capsule. The dosage prescribed by your healthcare provider will determine the specific strength you need.
  • The maximum dosage of Zenpep can vary depending on individual patient needs and the recommendation of a healthcare provider. Typically, the maximum daily dosage of Zenpep is based on the lipase units (LU) content, which can range from 75,000 to 150,000 LU per meal for adults. It’s important to follow your healthcare provider’s instructions regarding dosage, as they will tailor it to your specific medical condition and needs.

For example, if your healthcare provider prescribes Zenpep 25,000 lipase units per meal.

Given the example where you take Zenpep 25,000 lipase units per meal, three times a day:

  1. Daily dosage: 25,000 lipase units x 3 meals = 75,000 lipase units per day.
  2. Capsule strength: Assuming each Zenpep capsule contains 25,000 lipase units.
  3. Calculate the number of capsules needed for a 90-day supply:
    • Daily lipase units needed: 75,000 lipase units.
    • Number of capsules per day: Since each capsule is 25,000 lipase units, you would need 75,000 lipase units / 25,000 lipase units per capsule = 3 capsules per day.
    • Total capsules for 90 days: 3 capsules/day x 90 days = 270 capsules.

Therefore, for a 90-day supply, you would order approximately 270 capsules of Zenpep if you are prescribed 25,000 lipase units per meal and you eat three times a day.

It’s crucial to emphasize that the example provided is just that—an example. The actual dosage and quantity of Zenpep (pancrelipase) you should order for a 90-day supply must be determined by your healthcare provider based on your specific medical condition, the severity of your pancreatic enzyme deficiency, your diet, and other relevant factors.

How do I buy Zenpep from Canada?

To buy Zenpep from Canada:

  1. Visit Online Pharmacies Canada.
  2. Ensure you have a valid prescription.
  3. Place your order.
  4. Submit your prescription.
  5. Complete the payment process.

What is the cost of Zenpep in Canada?

At Online Pharmacies Canada, the cost of Zenpep is:

  • Zenpep 5000U / 100 capsules: From $402
  • Zenpep 15000U / 100 capsules: From $567
  • Zenpep 25000U / 100 capsules: From $1,055
  • Zenpep 40000U / 100 capsules: From $1,628

Do you ship Zenpep to the United States?

Yes, we ship Zenpep to both the United States and Puerto Rico.

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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Zenpep (Pancrelipase). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Zenpep (Pancrelipase).