Worsening Hepatitis B After Stopping Treatment
Do not stop taking Vemlidy without speaking with your healthcare provider.
Stopping hepatitis B treatment can cause the virus to become more active and may lead to a serious worsening of hepatitis B.
Your healthcare provider may monitor your liver function for several months after Vemlidy is stopped.
HIV-1 Infection and Drug Resistance
Vemlidy should not be used by itself to treat HIV-1 infection.
Before starting Vemlidy, your healthcare provider should test you for HIV.
If someone has both hepatitis B and HIV and takes Vemlidy alone, the HIV virus may become resistant to certain antiviral medications.
Kidney Problems
Vemlidy can cause new or worsening kidney problems. Rare cases of acute kidney failure and kidney tubule problems have also been reported.
The risk may be higher if you already have kidney disease or take other medicines that can affect the kidneys.
Your healthcare provider may monitor:
- Kidney function
- Urine protein
- Urine glucose
- Blood phosphorus if you have chronic kidney disease
Contact your healthcare provider if you notice major changes in urination, unusual weakness, swelling, or other symptoms of kidney problems.
Lactic Acidosis and Serious Liver Problems
Rarely, medicines in this drug class can cause lactic acidosis, which is a dangerous buildup of lactic acid in the blood.
They can also cause severe liver enlargement with fat buildup.
Seek medical attention if you develop symptoms such as:
- Severe weakness or tiredness
- Unusual muscle pain
- Trouble breathing
- Persistent nausea or vomiting
- Severe abdominal pain
- Dizziness or lightheadedness
- Yellowing of the skin or eyes
Drug Interactions
Vemlidy can interact with other medications.
Some drugs can lower the amount of Vemlidy in your body and make it less effective. Other medicines may increase the risk of kidney problems.
Tell your healthcare provider about all prescription medications, over-the-counter products, vitamins, supplements, and herbal products you use.
Particular caution may be needed with medications that strongly affect P-glycoprotein (P-gp) or kidney function.
Liver Problems
Vemlidy is used in people with chronic hepatitis B and compensated liver disease.
It is not recommended for people with moderate or severe decompensated liver disease.
Your healthcare provider may monitor your liver function regularly during treatment.
Pregnancy
Tell your healthcare provider if you are pregnant or planning to become pregnant.
Available pregnancy information has not shown a clear increased risk of major birth defects from tenofovir alafenamide, but your healthcare provider will consider the benefits and potential risks before recommending treatment.
Do not stop Vemlidy during pregnancy without medical advice, because stopping hepatitis B treatment can cause the infection to worsen.
Breastfeeding
Tell your healthcare provider if you are breastfeeding or planning to breastfeed.
Your healthcare provider will consider your treatment needs, the benefits of breastfeeding, and any potential risks to the infant before advising you.
Monitoring During Treatment
Your healthcare provider may order regular blood and urine tests while you are taking Vemlidy.
These tests may check:
- Liver function
- Kidney function
- Hepatitis B virus levels
- Urine protein and glucose
- Blood phosphorus in people with chronic kidney disease
Keep all scheduled follow-up appointments so your healthcare provider can make sure Vemlidy is working safely.
REVIEWS